Personalized GLP-1 plans drive real weight loss, few side effects, and strong adherence to care

Hims & Hers Health, Inc., the leading health and wellness platform, today released new data showing that its personalized, digital-first approach to weight loss is driving meaningful, sustainable results, laying the groundwork for lasting success. In a first-of-its-kind U.S. analysis of treatment plans, including compounded GLP-1s, customers taking a compounded GLP-1 reported losing an average of 20.9 pounds or 10.3% of initial body weight, within six months, while reporting a low rate of side effects. Just as importantly, 75% of customers remained on treatment plans in the same timeframe, a powerful signal of real-world trust and clinical success.¹

Unlike traditional care models that often leave patients to navigate treatment alone, Hims & Hers delivers access to a holistic weight loss program that combines personalized dosing when clinically necessary, 24/7 care team access, and educational support across nutrition, mental health, and physical wellness. The result: a scalable, high-quality model that empowers individuals, builds long-term trust, and helps people succeed.

Key findings from the new analysis indicate:

• Holistic model helps people stick with their treatment: While dropout rates for commercially available GLP-1s can hover around 80% at six months², only 25% of Hims & Hers customers discontinued treatment in that timeframe, highlighting the strength and confidence a holistic, personalized model delivers. While these results cannot be directly compared, it is encouraging that Hims & Hers customers appear to stick to their treatment plans in high numbers. 
• ‍Personalized treatment plans drive significant weight loss, with low rates of side effects and high safety: Customers lost an average of 20.9 pounds, or 10.3% of their initial body weight in six months. Among these same customers, only 10.3% reported side effects, and an even smaller 4.5% reported intolerable side effects. Among those who completed a 6-month check-in, 97% of customers on plans with compounded GLP-1s reported an improvement in their overall health.
• Always-on support empowers customers beyond the prescription: The platform combines 24/7 care team access with curated education across nutrition, mental health, and physical wellness. Customers exchanged over 6.7 million messages with their care teams, with 75% receiving responses in 5 hours or less.³ In fact, the majority of customers (73%) preferred their digital health experience with Hims & Hers over other programs or providers.⁴
• ‍Care in hours, not months, designed to scale without compromise: The average wait time to see an obesity medicine specialist in the U.S. is approximately 5 months.⁵ In contrast, the average wait time for a Hims & Hers Weight Loss customer to have their online medical intake evaluated by a licensed provider is approximately 3 hours.⁶

"My two decades as an obesity medicine specialist have shown me that lasting weight loss hinges on treating the individual, not just the condition. The true power of Hims & Hers lies in our ability to deliver access to truly bespoke care: from personalized dosing and tailored nutritional guidance to 24/7 access to reach out to their care team,” said Craig Primack MD, Head of Weight Loss, Hims & Hers. “Medication is a powerful component, but it's just one part of the comprehensive support system people need for this transformative health journey. Today's findings strongly signal that a digital-first, personalized experience is precisely what helps people stick to their treatment plans to drive lasting outcomes."

Download the full white paper here.